The RAD51C gene homepage
| General information |
| Gene symbol |
RAD51C |
| Gene name |
RAD51 homolog C (S. cerevisiae) |
| Chromosome |
17 |
| Chromosomal band |
q25.1 |
| Imprinted |
- |
| Genomic reference |
NG_023199.1 |
| Transcript reference |
NM_058216.1 |
| Associated with diseases |
WD |
| Citation reference(s) |
Pan M et al, 2011
Zhang T et al, 2010 |
| Refseq URL |
Coding DNA reference sequence |
| Curators (0) |
- |
| Total number of public variants reported |
30 |
| Unique public DNA variants reported |
26 |
| Individuals with public variants |
0 |
| Hidden variants |
- |
| Notes |
This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Also known as: FANCO; BROVCA3; RAD51L2 |
| Date created |
May 04, 2013 |
Active transcripts
| Copyright & disclaimer |
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