The ELAC2 gene homepage
| General information |
| Gene symbol |
ELAC2 |
| Gene name |
elaC homolog 2 (E. coli) |
| Chromosome |
17 |
| Chromosomal band |
p11.2 |
| Imprinted |
- |
| Genomic reference |
NG_015808.1 |
| Transcript reference |
NM_018127.6 |
| Associated with diseases |
WD |
| Citation reference(s) |
Pan M et al, 2011
Zhang T et al, 2010 |
| Refseq URL |
Coding DNA reference sequence |
| Curators (0) |
- |
| Total number of public variants reported |
61 |
| Unique public DNA variants reported |
42 |
| Individuals with public variants |
0 |
| Hidden variants |
- |
| Notes |
The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Also known as: ELC2; HPC2 |
| Date created |
April 19, 2013 |
Active transcripts
| Copyright & disclaimer |
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